Pair Name	Ginsenoside Rh2, Gemcitabine
Partner Name	Gemcitabine
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Biological Phenomena	Induction-->Immunomodulatory
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Up-regulation	Expression	BCL10	hsa8915
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	CARD9	hsa64170
	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Expression	MALT1	hsa10892
	Up-regulation	Expression	NFKB1	hsa4790
In Vitro Model	Panc02	Mouse pancreatic ductal adenocarcinoma	Mus musculus (Mouse)	CVCL_D627
	PANC-1	Pancreatic ductal adenocarcinoma	Homo sapiens (Human)	CVCL_0480
In Vivo Model	Orthotopic mouse model: Panc02 cells engineered to stably express firefly luciferase (1×10⁶) were mixed in an equal volume of Matrigel and were injected into the tail of pancreas of each mouse.
Result	Rh2 activation of DCs may remodel the cold TIME and optimize GEM chemotherapy for future therapeutic use.

Pair Name	Ginsenoside Rh2, Sodium selenite
Partner Name	Sodium selenite
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in G1/S phase
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	CASP3	hsa836
In Vitro Model	HCT 116	Colon carcinoma	Homo sapiens (Human)	CVCL_0291
Result	Sodium selenite and G-Rh2 combination have a synergistic effect on cell growth inhibition (57%) compared with sodium selenite (25%) and G-Rh2 alone (28%) after 24 hours of treatment

Pair Name	Ginsenoside Rh2, Anti-PD-L1 antibody
Partner Name	Anti-PD-L1 antibody
Disease Info	[ICD-11: 2A00-2F9Z]	Solid tumour or cancer		Investigative
Biological Phenomena	Induction-->Immunomodulatory
Gene Regulation	Up-regulation	Expression	IRF1	hsa3659
	Up-regulation	Phosphorylation	IRF3	hsa3661
	Up-regulation	Phosphorylation	STAT1	hsa6772
	Up-regulation	Phosphorylation	TBK1	hsa29110
In Vitro Model	MC-38	Mouse colon adenocarcinoma	Mus musculus (Mouse)	CVCL_B288
	CT26	Mouse colon adenocarcinoma	Mus musculus (Mouse)	CVCL_7254
	4T1	Malignant neoplasms of the mouse mammary gland	Mus musculus (Mouse)	CVCL_0125
In Vivo Model	The right flank of C57BL/6 mice were received with the subcutaneous injection of 1×10⁶ MC38 cells,2.5×105 4T1 cells or 1×10⁶ CT26 cells were subcutaneously injected into the right flank of BALB/c mice.
Result	These findings demonstrated that Rh2 potentiated the anti-cancer effect of PD-L1 blockade via promoting the T cells infiltration and activation, which shed a new light on the combination strategy to enhance anti-PD-L1 immunotherapy by using natural product Rh2.

Pair Name	Ginsenoside Rh2, Doxorubicin
Partner Name	Doxorubicin
Disease Info	[ICD-11:2D40]	Ehrlich's adenocarcinoma		Investigative
Gene Regulation	Up-regulation	Expression	NFE2L2	hsa4780
In Vivo Model	CD-1 albino mice were inoculated intraperitoneally (i.p.) with 0.5 mL PBS containing 3×10⁶ cells of Ehrlich’s adenocarcinoma (cells were derived from 7-day-old tumor re-transplanted into CD-1 mice).
Result	Rh2-induced direct activation of Nrf2 might provide additional benefits by minimizing DOX toxicity towards non-cancerous cells.